Multipe Sequence Alignments:
Identifying catalytic residues in an enzyme

catg_human (P08311)is a trypsin protease. Among its residues, identify those important for the conformation and those involved in the catalytic activity

Among many, try to answer the following questions:

  • a)Produce an informative multiple alignment (Choose active members).
  • b)Make a guess on the active residues.
  • c)Refine your model using proven inactive members of this family.

Questions should be sent to C.Notredame